Radix Angelicae Dahuricae extract,Imperatorin

English Name: imperatorin 98%

Other Name:  Ammidin, 8-Isoamylenoxypsoralen

Source:Cnidium monnieri (L.) Cuss

Pharmaceutical intermediate imperatorin 98%

Specification: 98%

Grade: Medical

CAS NO.: 482-44-0

Molecular formula: C16H14O4

Molecular weight: 270.27996

Appearance: White Crystalline powder

Description of Radix Angelicae Dahuricae extract,Imperatorin

Imperatorin is a furocoumarin and a phytochemical that has been isolated from Urena lobata L. (Malvaceae), Angelica archangelica, Angelica dahurica,Glehnia littoralis,Saposhnikovia divaricata, Cnidium monnieri, Incarvillea younghusbandii, and Zanthoxylum americanum mill. It is biosynthesized from umbelliferone, a coumarin derivative.

Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.

Function of Radix Angelicae Dahuricae extract,Imperatorin

1. Common cold due to wind-cold pathogens manifested as headache, stuffy nose, etc.

2. Headache, toothache, especially pain in the forehead and superciliary region.

3. Various infections on the body surface. For the treatment of acute mastitis, it is often used with trichosanthes fruit, fritillary bulb and dandelion; for various kinds of sores and swellings, it is often used with honey suckle flower, trichosanthes fruit and other drugs.

4. Leukorrhagia. For patients with profuse clear and thin leukorrhea due to cold-dampness, this drug is often used with white atractylodes rhizome, poria and cuttlebone; for foul yellow thick leukorrhagia due to damp-heat, it is used with phellodendron bark, plantain seed and other drugs.

Application of Radix Angelicae Dahuricae extract,Imperatorin

Imperatorin has antibacterial, anti-asthmatic and anti-allergy effect; for the scattered wind and dampness, Tongqiao pain, swelling and pus. For cold, headache, Mei Leng bone pain, nasal congestion, Bi Yuan, toothache, vaginal discharge, sore throat.