Three kinds of 15% L-Dopa in the chinese market
|
99% L-Dopa |
Source |
Process |
Environmental pollution |
Color |
|
|
Synthesis |
chemical synthesis to get the high purity L-Dopa |
high |
white |
It is possible to come out D-Dopa which is harmful human body |
|
|
Solvent extract (strong acid and strong base) |
First get the crude extract(50-85% L-Dopa),the Concentrate,refine to get the high purity |
high |
white |
It is possible to residual solvent |
|
|
Water extract |
Get extract from low purity to high purity step by step |
low |
white |
None |
|
15% L-Dopa |
Source |
Process |
Environmental pollution |
Color |
Active ingredient |
|
Synthesis |
High purity Synthesis L-Dopa, add dextrin to 15% |
high |
white |
None active substance of Mucuna Pruriens |
|
|
Solvent extract (strong acid and strong base) |
High purity solven extract L-Dopa,add dextrin to 15% |
high |
white |
Less content active substance of Mucuna Pruriens |
|
|
Water extract |
Get the 15% powder step by step |
low |
Light brown |
High content active substance of Mucuna Pruriens |
Pictures:
Extraction Process and Specifications
of Levodopa
Part 1. Extraction process from ours and others
Water Extraction Process :Raw materials(Mucuna Pruriens) → Crushing → Extract→ Concentrate① → Precipitation② → Refining③ → Drying → Standard production
Solvent Extraction Process:
Raw materials(mucuna pruriens) → Crushing → Extract → Column Chromatography →
Strong acid neutralization→ Concentrate → Precipitation① → Refining② → Drying → Standard production
Part 2. Extraction Process comparison table
|
Project |
Water Extraction Process |
Solvent Extraction Process |
Remarks |
|
Use of strong acid |
─ |
√ |
Extraction Processing |
|
─ |
√ |
Column Chromatography Processing |
|
|
Ammonia - acetic acid elution |
─ |
√ |
Column Chromatography Processing |
|
Strong acid neutralization |
─ |
√ |
Eluent processing |
Note：“—”state non used，“√”state ued.
Intruction:
Acccording to Extraction process
1(concentrate ①, precipitation ②, refining ③) , the obtained specification of levodopa is different. (Water Extraction can obtain 15%- 20% levodopa from
Concentrating ①; Water Extraction can obtain 80% levodopa from precipitation; Water
Extraction can obtain levodopa content over 90% from refining③.
Acccording to The Solvent
Extraction process , over 50-85% levodopa can be obtained from precipitation①, over 90% levodopa can be obtained from refining②.
Part 3. Specification
Under the condition of not adding
other substances, according to the process and customers’ requirements, Water
Extraction can produce different specifications of levodopa(especially the
content ＜ 90%) which contains other ingredients like
amino acids and proteins of Mucuna Pruriens.
However using other method to produce content ＜80% levodopa(like use
dextrin as diluent for content adjustments) , the product does not contain
ingredients like amino acids and proteins of Mucuna Pruriens..
Testing the other amino acids and
protein from the product can judge the process deference.
Active ingredient difference:
plantextractpowder